Skip to main navigation menu Skip to main content Skip to site footer

Vol. 15 No. 4 (2023)

Articles

PRE AND POST BLOOD TRANSFUSION DISTRIBUTION OF RHESUS C AND E AMONG RECIPIENTS OF BLOOD IN AWKA AND ASABA, NIGERIA.

Published 2023-04-30

  • C. Chinedum Onyenekwe
    • ,
  • U. Modestus Ezugwu
    • ,
  • N. Ogochukwu Enyenekwe
    • ,
  • O. Nosa Osakue
    • ,
  • S. Ifeoma Obu
    • ,
  • F. Alfred Ehiaghe
    • ,
  • N. Eric
    • ,
  • Achiaku Akaahan
    • ,
  • S. Eno Edet
    • ,
  • I. Joy Ehiaghe

C. Chinedum Onyenekwe
Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra, Nigeria

U. Modestus Ezugwu
Department of Medical Laboratory Services, Regina Ceali Hospital, Awka, Anambra State, Nigeria.

N. Ogochukwu Enyenekwe
Department of Mass Communication, Nnamdi Azikiwe University, Awka, Anambra, Nigeria

O. Nosa Osakue
Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra, Nigeria

S. Ifeoma Obu
Department of Medical Laboratory Science, Federal Medical Centre Asaba, Delta State, Nigeria

F. Alfred Ehiaghe
Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra, Nigeria

N. Eric
Department of Family Medicine, Federal Medical Centre, Asaba, Delta State.

Achiaku Akaahan
Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra, Nigeria

S. Eno Edet
Department of Medical Laboratory Science, Federal Medical Centre Asaba, Delta State, Nigeria

I. Joy Ehiaghe
Department of Medical Laboratory Science, Benson Idahosa University, Benin City, Edo State Nigeria

Abstract

Rhesus c and e red cell antigens are among the highly immunogenic Rhesus antigens after Rhesus D. This study was designed to determine the Rhesus c/e transfusion outcome among recipients of blood transfusion. 71 intending blood recipients were recruited consecutively for the study. The tube agglutination reactions between monoclonal Anti-c and Anti-e reagents and 3% red cell suspension of the participants was used to identify Rhesus c/e antigen on the red cells. The result showed that Out of the 71 intending blood recipients 42(59%) had Rhesus c+/e+; 26(36.6%) had Rhesus c-/e- status; 1(1.4%) had Rhesus c+/e- status and 2(2.8%) had Rhesus c-/e+ status. Amongst the recipient post-blood transfusion 52(73.3%) had Rhesus c+/e+ status; 18(25.4%) had Rhesus c+/e- status; 1(1.4%) had Rhesus c-/e+ status and none had Rhesus c-/e+ status. Post- Blood transfusion 14(20%) of the recipients had a change in Rhesus status from Rhesus c-/e- to Rhesus c+/e+; 1(1.4%) of the recipients had a change from
Rhesus c-/e- to Rhesus e-/c+ while 2(2.8%) of the recipients had their Rhesus c-/e+ changed to Rhesus c+/e+ and 1(1.4%) of the recipients had Rhesus c+/e- changed to Rhesus c+/e+. The finding is suggestive that Rhesus c/e antigens should be screened as part of compatibility test before blood transfusion. The addition of Rhesus c/e in the cross match panel in Nigeria may eliminate about 25% post transfusion sensitization. 

Keywords

Rhesus antigens, Blood donors, Blood recipients, transfusion, cross-match

PDF