PRE AND POST BLOOD TRANSFUSION DISTRIBUTION OF RHESUS C AND E AMONG RECIPIENTS OF BLOOD IN AWKA AND ASABA, NIGERIA.
Rhesus c and e red cell antigens are among the highly immunogenic Rhesus antigens after Rhesus D. This study was designed to determine the Rhesus c/e transfusion outcome among recipients of blood transfusion. 71 intending blood recipients were recruited consecutively for the study. The tube agglutination reactions between monoclonal Anti-c and Anti-e reagents and 3% red cell suspension of the participants was used to identify Rhesus c/e antigen on the red cells. The result showed that Out of the 71 intending blood recipients 42(59%) had Rhesus c+/e+; 26(36.6%) had Rhesus c-/e- status; 1(1.4%) had Rhesus c+/e- status and 2(2.8%) had Rhesus c-/e+ status. Amongst the recipient post-blood transfusion 52(73.3%) had Rhesus c+/e+ status; 18(25.4%) had Rhesus c+/e- status; 1(1.4%) had Rhesus c-/e+ status and none had Rhesus c-/e+ status. Post- Blood transfusion 14(20%) of the recipients had a change in Rhesus status from Rhesus c-/e- to Rhesus c+/e+; 1(1.4%) of the recipients had a change from
Rhesus c-/e- to Rhesus e-/c+ while 2(2.8%) of the recipients had their Rhesus c-/e+ changed to Rhesus c+/e+ and 1(1.4%) of the recipients had Rhesus c+/e- changed to Rhesus c+/e+. The finding is suggestive that Rhesus c/e antigens should be screened as part of compatibility test before blood transfusion. The addition of Rhesus c/e in the cross match panel in Nigeria may eliminate about 25% post transfusion sensitization.
Rhesus antigens, Blood donors, Blood recipients, transfusion, cross-match